DDMODEL00000039: IVGTT Integrated glucose insulin modeI (IGI)

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Short description:
An integrated model for the regulation of glucose and insulin concentrations following intravenous glucose provocations in healthy volunteers and type 2 diabetic patients
Original code
  • An integrated model for glucose and insulin regulation in healthy volunteers and type 2 diabetic patients following intravenous glucose provocations.
  • Silber HE, Jauslin PM, Frey N, Gieschke R, Simonsson US, Karlsson MO
  • Journal of clinical pharmacology, 9/2007, Volume 47, Issue 9, pages: 1159-1171
  • Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, University of Uppsala, Sweden.
  • An integrated model for the regulation of glucose and insulin concentrations following intravenous glucose provocations in healthy volunteers and type 2 diabetic patients was developed. Data from 72 individuals were included. Total glucose, labeled glucose, and insulin concentrations were determined. Simultaneous analysis of all data by nonlinear mixed effect modeling was performed in NONMEM. Integrated models for glucose, labeled glucose, and insulin were developed. Control mechanisms for regulation of glucose production, insulin secretion, and glucose uptake were incorporated. Physiologically relevant differences between healthy volunteers and patients were identified in the regulation of glucose production, elimination rate of glucose, and secretion of insulin. The model was able to describe the insulin and glucose profiles well and also showed a good ability to simulate data. The features of the present model are likely to be of interest for analysis of data collected in antidiabetic drug development and for optimization of study design.
Moustafa Ibrahim
Context of model development: Mechanistic Understanding;
Long technical model description: The objective of this work was to develop an integrated model of glucose and insulin. The term integrated here indicates that the model is simultaneously fitted to both glucose and insulin observations by including the control mechanisms between the 2 entities,The model presented here was developed for use in drug development and analysis of clinical studies. The present model could be used for analysis of the effects of antidiabetic drugs on the glucose-insulin system from a more mechanistic point of view than what has been possible with previous models. This would increase the understanding of the effects of different types of drugs on a physiological system. Another application of this model could be the optimization of trial designs traditionally used to study the glucose insulin system because these are highly standardized. The designs are typically both time consuming and intensive in sampling, but with the use of population techniques it would be possible to reduce the number of sampling points needed. This may result in less expensive trials and would also reduce the inconvenience for patients.;
Model compliance with original publication: Yes;
Model implementation requiring submitter’s additional knowledge: No;
Modelling context description: An integrated model for the regulation of glucose and insulin concentrations following intravenous glucose provocations in healthy volunteers and type 2 diabetic patients,The model was able to describe the insulin and glucose profiles well and also showed a good ability to simulate data. The features of the present model are likely to be of interest for analysis of data collected in antidiabetic drug development and for optimization of study design.;
Modelling task in scope: estimation;
Nature of research: Clinical research & Therapeutic use;
Therapeutic/disease area: Endocrinology;
Annotations are correct.
This model is not certified.
  • Model owner: Moustafa Ibrahim
  • Submitted: Dec 11, 2015 11:28:28 AM
  • Last Modified: Jun 3, 2016 5:02:24 PM
Revisions
  • Version: 12 public model Download this version
    • Submitted on: Jun 3, 2016 5:02:24 PM
    • Submitted by: Moustafa Ibrahim
    • With comment: Edited model metadata online.
  • Version: 10 public model Download this version
    • Submitted on: Jun 3, 2016 4:58:49 PM
    • Submitted by: Moustafa Ibrahim
    • With comment: Model revised without commit message
  • Version: 6 public model Download this version
    • Submitted on: Dec 11, 2015 11:28:28 AM
    • Submitted by: Moustafa Ibrahim
    • With comment: Edited model metadata online.
 
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