Model to describe the time-course of leukocytes (total white blood cell counts) following administration of paclitaxel with linear concentration-effect relationship.
|Context of model development:||Mechanistic Understanding;|
|Discrepancy between implemented model and original publication:||The model is the same, some accomodations on the dataset were needed;|
|Long technical model description:||The model consists of one compartment representing drug-sensitive cells in the bone marrow, three compartments representing the maturation of the white blood cells and one compartment for the circulating cells, where the measurements had been done. A feedback mechanism triggered by the number of circulting cells was implemented over the proliferation rate constant. The drug effect was described by Emax-model.;|
|Model compliance with original publication:||Yes;|
|Model implementation requiring submitter’s additional knowledge:||No;|
|Modelling context description:||chemotherapy-induced myelosuppression through drug-specific parameters and system-related parameters, common to all drugs;|
|Modelling task in scope:||estimation;|
|Nature of research:||Clinical research & Therapeutic use;|
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This model is not certified.
- Model owner: Zinnia Parra-Guillen
- Submitted: Jul 15, 2016 12:14:56 PM
- Last Modified: Aug 24, 2016 9:03:17 AM
Independent variable T
Structural Model sm
Continuous covariate CLI
Continuous covariate V1I
Continuous covariate V2I
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Continuous / Residual Data
Estimation Step estimStep_1
Initial estimates for non-fixed parameters
1) Estimate the population parameters