DDMODEL00000228: Alskär 2015 Gastric emptying and glucose absorption model

  public model
Short description:
Model describing gastric emptying and glucose absortption after oral glucose tolerance tests in healthy controls and patients with type 2 diabetes.
Original code
  • Semimechanistic Model Describing Gastric Emptying and Glucose Absorptionin Healthy Subjects and Patients With Type2 Diabetes
  • Oskar Alskär, Jonatan I Bagger, Rikke M Roge, Filip K Knop, Mats O Karlsson, Tina Vilsbøll, Maria C Kjellsson
  • Journal of Clinical Pharmacology, 10/2015, Volume 56, Issue 3, pages: 340-348
  • Department of Pharmaceutical Biosciences, Uppsala University, Sweden
  • The integrated glucose-insulin (IGI) model is a previously published semimechanistic model that describes plasma glucose and insulin concentrations after glucose challenges. The aim of this work was to use knowledge of physiology to improve the IGI model's description of glucose absorption and gastric emptying after tests with varying glucose doses. The developed model's performance was compared to empirical models. To develop our model, data from oral and intravenous glucose challenges in patients with type 2 diabetes and healthy control subjects were used together with present knowledge of small intestinal transit time, glucose inhibition of gastric emptying, and saturable absorption of glucose over the epithelium to improve the description of gastric emptying and glucose absorption in the IGI model. Duodenal glucose was found to inhibit gastric emptying. The performance of the saturable glucose absorption was superior to linear absorption regardless of the gastric emptying model applied. The semiphysiological model developed performed better than previously published empirical models and allows better understanding of the mechanisms underlying glucose absorption. In conclusion, our new model provides a better description and improves the understanding of dynamic glucose tests involving oral glucose.
Oskar Alskär
Context of model development: Mechanistic Understanding;
Model compliance with original publication: Yes;
Model implementation requiring submitter’s additional knowledge: No;
Modelling context description: Gastric emptying together with glucose absorption (rate and extent) affects glucose exposure after oral glucose tolerance tests.;
Modelling task in scope: estimation;
Nature of research: Early clinical development (Phases I and II);
Therapeutic/disease area: Endocrinology;
Annotations are correct.
This model is not certified.
  • Model owner: Oskar Alskär
  • Submitted: Oct 17, 2016 3:38:55 PM
  • Last Modified: Oct 17, 2016 3:38:55 PM
  • Version: 16 public model Download this version
    • Submitted on: Oct 17, 2016 3:38:55 PM
    • Submitted by: Oskar Alskär
    • With comment: Edited model metadata online.