DDMODEL00000247: Morphine PD in newborns on mechanical ventillation using item response theory (IRT)

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  • Morphine Pharmacodynamics in Mechanically Ventilated Preterm Neonates Undergoing Endotracheal Suctioning.
  • Välitalo PA, Krekels EH, van Dijk M, Simons S, Tibboel D, Knibbe CA
  • CPT: Pharmacometrics & Systems Pharmacology, 4/2017, Volume 6, Issue 4, pages: 239-248
  • Division of Pharmacology, Leiden University, Leiden, The Netherlands.
  • To date, morphine pharmacokinetics (PKs) are well quantified in neonates, but results about its efficacy are ambiguous. This work presents an analysis of a previously published study on pain measurements in mechanically ventilated preterm neonates who received either morphine or placebo to improve comfort during invasive ventilation. The research question was whether morphine reduces the pain associated with endotracheal or nasal suctioning before, during, and after suctioning. Because these neonates cannot verbalize their pain levels, pain was assessed on the basis of several validated pain measurement instruments (i.e., COMFORT-B, preterm infant pain profile [PIPP], Neonatal Infant Pain Scale (NIPS), and visual analogue scale (VAS)). The item response theory (IRT) was used to analyze the data in order for us to handle the data from multiple-item pain scores. The analysis showed an intra-individual relationship between morphine concentrations and pain reduction, as measured by COMFORT-B and VAS. However, the small magnitude of the morphine effect was not considered clinically relevant for this intervention in preterm neonates.
Catherijne Knibbe
Context of model development: Dose & Schedule Selection and Label Recommendation;
Model compliance with original publication: Yes;
Model implementation requiring submitter’s additional knowledge: No;
Modelling context description: Item response theory (IRT) was used to quantify the effect of morphine on pain around endotrachial succtioning in newborns that are mechanically ventilated.;
Modelling task in scope: estimation;
Nature of research: Clinical research & Therapeutic use;
Therapeutic/disease area: CNS;
Annotations are correct.
This model is not certified.
  • Model owner: Catherijne Knibbe
  • Submitted: Oct 9, 2017 1:26:24 PM
  • Last Modified: Oct 9, 2017 1:26:24 PM
  • Version: 10 public model Download this version
    • Submitted on: Oct 9, 2017 1:26:24 PM
    • Submitted by: Catherijne Knibbe
    • With comment: Updated model annotations.