DDMODEL00000294: Executable_Paracetamol_Zebrafish_345dpf

  public model
Short description:
Paracetamol pharmacokinetics in zebrafish larvae of 3, 4, and 5 dpf including age as covariate on absorption and elimination.
Original code
Rob Christiaan van Wijk
Context of model development: Variability sources in PK and PD (CYP, Renal, Biomarkers);
Long technical model description: Zebrafish larvae of 3, 4, and 5 dpf have been treated with 1 mM paracetamol in surrounding medium for designated times after which internal exposure is quantified in homogenates (destructive sampling). Model identifies age as covariate on absorption (discrete, changed between 3 and 4 dpf) and on elimination (power relation, 17.5% increased elimination per day post fertilisation). Error model is combination of additive and proportional. ;
Model compliance with original publication: Yes;
Model implementation requiring submitter’s additional knowledge: No;
Modelling context description: Impact of age on absorption and elimination of paracetamol by zebrafish larvae;
Modelling task in scope: estimation;
Nature of research: Fundamental/Basic research;
Annotations are correct.
This model is not certified.
  • Model owner: Rob Christiaan van Wijk
  • Submitted: Jan 4, 2019 8:53:51 AM
  • Last Modified: Jan 4, 2019 8:53:51 AM
  • Version: 12 public model Download this version
    • Submitted on: Jan 4, 2019 8:53:51 AM
    • Submitted by: Rob Christiaan van Wijk
    • With comment: Model revised without commit message