DDMODEL00000297: Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women
Short description:
Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Burkina Faso
Original code |
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Joel Tarning
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| Context of model development: | Variability sources in PK and PD (CYP, Renal, Biomarkers); |
| Discrepancy between implemented model and original publication: | None; |
| Long technical model description: | A detailed explanation of the model can be found in the published manuscript, Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Burkina Faso (published at Wellcome Open Research); |
| Model compliance with original publication: | Yes; |
| Model implementation requiring submitter’s additional knowledge: | No; |
| Modelling context description: | Acquiring a malaria infection during pregnancy has been associated with adverse health outcomes for both the mother and the foetus. The aim of this model was to describe the pharmacokinetic properties of artesunate and its metabolite dihydroartemisinin in non-pregnant and pregnant women; |
| Modelling task in scope: | estimation; |
| Nature of research: | Clinical research & Therapeutic use; |
| Therapeutic/disease area: | Anti-infectives; |
Annotations are correct. |
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This model is not certified. |
- Model owner: Joel Tarning
- Submitted: Feb 15, 2019 8:02:22 AM
- Last Modified: Feb 15, 2019 8:02:22 AM
Revisions
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Version: 33
- Submitted on: Feb 15, 2019 8:02:22 AM
- Submitted by: Joel Tarning
- With comment: Edited model metadata online.
Build info: 883dad825 | Tue, 29 May 2018 18:40:51