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DDMODEL00000298: Executable_sultiame_nonlinear_PK

Short description:
The model describes the PK of sultiame after administration of three single oral doses of 50, 100 and 200 mg in open-label at four to six weeks interval in 4 healthy volunteers. Serial measurements in plasma, erythrocytes and urines were performed. The plasma maximal concentrations (Cmax) showed striking non-linear disposition of sultiame, with a ten-fold increase while doses were doubled. Conversely, whole blood Cmax increased less than dose-proportionally whilst staying much higher than in plasma.
A three-compartment model incorporating a saturable ligand to receptor binding was devised. The model was expressed in terms of differential equations and first-order rate constants of absorption (ka), elimination (ke), association to (kon) and dissociation from (koff) receptors, maximal binding capacity (Btot), apparent central volume of distribution (V2) and erythrocytes’ volume of distribution (V3).
Original code |
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Kim Dao, Thierry Buclin
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Annotations are correct. |
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This model is not certified. |
- Model owner: Kim Dao
- Submitted: Jun 24, 2019 8:13:44 AM
- Last Modified: Oct 18, 2019 3:18:13 PM
Revisions
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Version: 21
- Submitted on: Oct 18, 2019 3:18:13 PM
- Submitted by: Kim Dao
- With comment: Edited model metadata online.
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Version: 19
- Submitted on: Oct 18, 2019 2:20:33 PM
- Submitted by: Thierry Buclin
- With comment: Updated model annotations.
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Version: 18
- Submitted on: Oct 7, 2019 8:25:45 AM
- Submitted by: Kim Dao
- With comment: Model revised without commit message
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Version: 16
- Submitted on: Jul 16, 2019 3:51:31 PM
- Submitted by: Thierry Buclin
- With comment: Updated model annotations.
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Version: 15
- Submitted on: Jun 25, 2019 8:14:09 AM
- Submitted by: Kim Dao
- With comment: Edited model metadata online.
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Version: 13
- Submitted on: Jun 25, 2019 8:11:24 AM
- Submitted by: Kim Dao
- With comment: Model revised without commit message
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Version: 10
- Submitted on: Jun 24, 2019 8:13:44 AM
- Submitted by: Kim Dao
- With comment: Updated model annotations.